Search results for "Working hypothesis"
showing 10 items of 12 documents
Does SARS-CoV-2 Trigger Stress-InducedAutoimmunity by Molecular Mimicry? A Hypothesis.
2020
Viruses can generate molecular mimicry phenomena within their hosts. Why shouldsevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) not be considered one of these?Information in this short review suggests that it might be so and, thus, encourages research aimingat testing this possibility. We propose, as a working hypothesis, that the virus induces antibodiesand that some of them crossreact with host’s antigens, thus eliciting autoimmune phenomena withdevasting consequences in various tissues and organs. If confirmed, by in vitro and in vivo tests,this could drive researchers to find effective treatments against the virus.
Biomarkers and Inflammatory Network in Aging
2014
Abstract Humans are characterized by a large heterogeneity in lifespans. The aging rate, measured as a decline of functional capacity and stress resistance, is different in every individual. Several attempts have been made to define the so-called biological age, but without achieving real success. Biomarkers of aging, which are represented by biological indicators selected using appropriate criteria, should help to characterize the biological age. Since age is a major risk factor in many degenerative diseases, such biomarkers could subsequently be used to identify individuals at a high risk of developing age-associated diseases or disabilities. In this chapter, some inflammatory biomarkers …
Valores y tiempo libre. Desafíos éticos de las redes sociales a la educación moral
2012
El objetivo de estas páginas es analizar la relación entre la educación en valores y las organizaciones juveniles que promueven una educación democrática, también llamadas organizaciones de tiempo libre. El análisis describe los desafíos éticos que las TIC y las redes sociales plantean en el ámbito de la educación democrática como determinación de la educación moral. Análisis que se plantea como ejercicio de ética aplicada para promover la deliberación moral y la investigación interdisciplinar en los ámbitos socio–educativos. Utilizaremos la hermenéutica crítica como método que contribuye a la clarificación de las categorías éticas que intervienen en los proyectos de vida moral. La hipótesis…
Depleted uranium induces human carcinogenesis involving the immune and chaperoning systems: Realities and working hypotheses
2019
Abstract Cancer is caused by a combination of factors, genetic, epigenetics and environmental. Among the latter, environmental pollutants absorbed by contact, inhalation, or ingestion are major proven or suspected culprits. Depleted uranium (DU) is one of them directly pertinent to the military and civilians working in militarized areas. It is considered a weak carcinogen but its implication in cancer development in exposed individuals is supported by various data. Since not all subjects exposed to DU develop cancer, it is likely that DU-dependent carcinogenesis requires cofactors, such as genetic predisposition and deficiencies of the chaperoning and immune systems. It is of the essence to…
Is there contextuality in behavioural and social systems?
2015
Most behavioral and social experiments aimed at revealing contextuality are confined to cyclic systems with binary outcomes. In quantum physics, this broad class of systems includes as special cases Klyachko-Can-Binicioglu-Shumovsky-type, Einstein-Podolsky-Rosen-Bell-type, and Suppes-Zanotti-Leggett-Garg-type systems. The theory of contextuality known as Contextuality-by-Default allows one to define and measure contextuality in all such system, even if there are context-dependent errors in measurements, or if something in the contexts directly interacts with the measurements. This makes the theory especially suitable for behavioral and social systems, where direct interactions of "everythin…
Clusters of Traders in Financial Markets
2020
In this chapter we discuss Aoki’s work on the description of clusters of economic agents acting in a market. Specifically, we briefly discuss his work on the Ewens distribution and its application in a model of stock market with heterogeneous agents. We then review recent empirical analyses on the heterogeneity of financial market participants and make a working hypothesis for an empirical study on the distribution of the number of clusters of market participants in a real stock market monitored with a resolution down to the shadowed identity of market participants.
Towards a tractable working hypothesis for deimatic displays
2016
Stress as a Key Concept in Chronic Widespread Pain and Fatigue Disorders
2009
ABSTRACT.Objectives: To review recent studies on the etiopathogenetic role and clinical relevance of life stress in medically unexplained syndromes characterized by chronic widespread musculoskeletal pain and fatigue.Findings: Both fibromyalgia syndrome [FMS] and chronic fatigue syndrome [CFS] have been found to be frequently linked to different stressors, such as negative life events, occupational problems, posttraumatic stress [PTSD], adverse childhood experiences, and “overactive” lifestyle. In addition, the stress-modulating role of affect-regulation, perceptual-cognitive factors, and social support, as well as the relationship with depression have been investigated in FMS/CFS patients.…
Modelling the regenerative niche: a major challenge in biomaterials research
2015
By definition, biomaterials are developed for clinical application. In the field of regenerative medicine their principal function is to play a significant, and, if possible, an instructive role in tissue healing. In the last analysis the latter involves targeting the 'regenerative niche'. The present paper will address the problem of simulating this niche in the laboratory and adopts a life science approach involving the harnessing of heterotypic cellular communication to achieve this, that is, the ability of cells of different types to mutually influence cellular functions. Thus, co-culture systems using human cells are the methodological focus and will concern four exemplary fields of re…
Ratures fécondes
2012
Commenting on daily life of the scientific community, newspapers highlight some characteristics of the way sciences are evolving, thanks to a kind of epistemological flash-back : the way they lean on working hypothesis, these working hypothesis leaning themselves on on-going dogma. These comments on scientific current affairs call for a new understanding of gradual corrections of hypothesis.